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Numerous investigation teams have utilized LC–MS-MS for willpower of artificial cannabinoids in herbs and biological samples, plus some have analyzed the fragmentation of synthetic cannabinoids in detail [15, 31]. The possible fragmentation pathways are shown in Fig. 4. Because the protonated molecular ion is simply observed by LC–MS, and the knowledge obtained by LC–MS is lesser than that for GC–MS, it is necessary to obtain other info that mirror the chemical constructions by LC–MS-MS or TOFMS.
Notes: (one) TAAR1 activity of ligands may differ appreciably concerning species. Some agents which are TAAR1 ligands in certain species are certainly not in other species.
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